If youve looked into GLP-1 therapy for weight loss, youve almost certainly run into both semaglutide and tirzepatide
NICE guidance on obesity and weight management recognises that sustained weight loss of 10% or more can significantly reduce the risk of type 2 diabetes, cardiovascular disease, and musculoskeletal problems
However, the relationship between GLP-1 therapy and breathing difficulties warrants careful consideration, as respiratory symptoms can occur in the context of GLP-1 treatment through indirect mechanisms
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One significant finding is from the SELECT trial, which showed that long-term use of semaglutide in individuals with obesity but without diabetes led to a 20% reduction in major cardiovascular events and an average weight loss of 9.4%
These behavioral shifts indicate your medication is working correctly, even if water retention or initial inflammation temporarily masks weight loss